Incentivizing the Dissemination of Truth Versus Fake News in Social Networks

The concept of truth, as a public good is the production of a collective understanding, which emerges from a complex network of social interactions. The recent impact of social networks on shaping the perception of truth in political arena shows how such perception is corroborated and established by the online users, collectively. However, investigative journalism for discovering truth is a costly option, given the vast spectrum of online information. In some cases, both journalist and online users choose not to investigate the authenticity of the news they receive, because they assume other actors of the network had carried the cost of validation. Therefore, the new phenomenon of "fake news" has emerged within the context of social networks. The online social networks, similarly to System of Systems, cause emergent properties, which makes authentication processes difficult, given availability of multiple sources. In this study, we show how this conflict can be modeled as a volunteer's dilemma. We also show how the public contribution through news subscription (shared rewards) can impact the dominance of truth over fake news in the network.Comment: System of Systems Engineering Conference (SoSE), 2017 12th. IEEE, 201

Conceptual Modeling of the Impact of Smart Cities on Household Energy Consumption

AbstractSmart cities provide citizens with information on various urban services and allow them to track the impact of their resource consumption on the overall sustainability of their city. The premise of smart cities is that with improved access to information on resource consumption, residents make better use of those resources, resulting in increased sustainability of the city.This paper explores the influence of the smart city technologies on individuals’ resource consumption behavior, in particular on energy consumption, aiming at achieving environmentally sustainable development. This approach combines systems thinking with existing social science theories, such as cognitive and learning theories, to explore the impact of smart city information on individual decision-making and behavioral change. Using a CLIOS (complex, large-scale, interconnected, open, and sociotechnical) model, a conceptual soft systems model, the paper explores the impact of smart city technologies on behavioral change of households with regards to energy consumption

Managing Vulnerabilities of Tactical Wireless RF Network Systems: A Case Study

Organisations and individuals benefit when wireless networks are protected. After assessing the risks associated with wireless technologies, organisations can reduce the risks by applying countermeasures to address specific threats and vulnerabilities. These countermeasures include management, operational and technical controls. While these countermeasures will not prevent all penetrations and adverse events, they can be effective in reducing many of the common risks associated with wireless RF networks. Among engineers dealing with different scaled and interconnected engineering systems, such as tactical wireless RF communication systems, there is a growing need for a means of analysing complex adaptive systems. We propose a methodology based on the systematic resolution of complex issues to manage the vulnerabilities of tactical wireless RF systems. There are is a need to assemble and balance the results of any successful measure, showing how well each solution meets the system’s objectives. The uncertain arguments used and other test results are combined using a form of mathematical theory for their analysis. Systems engineering thinking supports design decisions and enables decision‐makers to manage and assess the support for each solution. In these circumstances, complexity management arises from the many interacting and conflicting requirements of an increasing range of possible parameters. There may not be a single ‘right’ solution, only a satisfactory set of resolutions which this system helps to facilitate. Smart and innovative performance matrixes are introduced using a mathematical Bayesian network to manage, model, calculate and analyse all the potential vulnerability paths in wireless RF networks

Pursuing Gravitational S-Duality

Recently a strong-weak coupling duality in non-abelian non-supersymmetric theories in four dimensions has been found. An analogous procedure is reviewed, which allows to find the `dual action' to the gauge theory of dynamical gravity constructed by the MacDowell-Mansouri model plus the superposition of a $\Theta$ term.Comment: Invited paper to appear in the special issue of the `Journal of Chaos, Solitons and Fractals' on: "Superstrings, M,F,S,... Theory" (M.S. El Naschie and C. Castro, editors), 19 pages, LaTeX file, no figure

Mifepristone prevents repopulation of ovarian cancer cells escaping cisplatin-paclitaxel therapy

<p>Abstract</p> <p>Background</p> <p>Advanced ovarian cancer is treated with cytoreductive surgery and combination platinum- and taxane-based chemotherapy. Although most patients have acute clinical response to this strategy, the disease ultimately recurs. In this work we questioned whether the synthetic steroid mifepristone, which as monotherapy inhibits the growth of ovarian cancer cells, is capable of preventing repopulation of ovarian cancer cells if given after a round of lethal cisplatin-paclitaxel combination treatment.</p> <p>Methods</p> <p>We established an <it>in vitro</it> approach wherein ovarian cancer cells with various sensitivities to cisplatin or paclitaxel were exposed to a round of lethal doses of cisplatin for 1 h plus paclitaxel for 3 h. Thereafter, cells were maintained in media with or without mifepristone, and short- and long-term cytotoxicity was assessed.</p> <p>Results</p> <p>Four days after treatment the lethality of cisplatin-paclitaxel was evidenced by reduced number of cells, increased hypodiploid DNA content, morphological features of apoptosis, DNA fragmentation, and cleavage of caspase-3, and of its downstream substrate PARP. Short-term presence of mifepristone either enhanced or did not modify such acute lethality. Seven days after receiving cisplatin-paclitaxel, cultures showed signs of relapse with escaping colonies that repopulated the plate in a time-dependent manner. Conversely, cultures exposed to cisplatin-paclitaxel followed by mifepristone not only did not display signs of repopulation following initial chemotherapy, but they also had their clonogenic capacity drastically reduced when compared to cells repopulating after cisplatin-paclitaxel.</p> <p>Conclusions</p> <p>Cytostatic concentrations of mifepristone after exposure to lethal doses of cisplatin and paclitaxel in combination blocks repopulation of remnant cells surviving and escaping the cytotoxic drugs.</p

The Effect of Sensory Uncertainty Due to Amblyopia (Lazy Eye) on the Planning and Execution of Visually-Guided 3D Reaching Movements

Background: Impairment of spatiotemporal visual processing in amblyopia has been studied extensively, but its effects on visuomotor tasks have rarely been examined. Here, we investigate how visual deficits in amblyopia affect motor planning and online control of visually-guided, unconstrained reaching movements. Methods: Thirteen patients with mild amblyopia, 13 with severe amblyopia and 13 visually-normal participants were recruited. Participants reached and touched a visual target during binocular and monocular viewing. Motor planning was assessed by examining spatial variability of the trajectory at 50–100 ms after movement onset. Online control was assessed by examining the endpoint variability and by calculating the coefficient of determination (R 2) which correlates the spatial position of the limb during the movement to endpoint position. Results: Patients with amblyopia had reduced precision of the motor plan in all viewing conditions as evidenced by increased variability of the reach early in the trajectory. Endpoint precision was comparable between patients with mild amblyopia and control participants. Patients with severe amblyopia had reduced endpoint precision along azimuth and elevation during amblyopic eye viewing only, and along the depth axis in all viewing conditions. In addition, they had significantly higher R 2 values at 70 % of movement time along the elevation and depth axes during amblyopic eye viewing. Conclusion: Sensory uncertainty due to amblyopia leads to reduced precision of the motor plan. The ability to implemen

Stem Cells, Self-Renewal, and Lineage Commitment in the Endocrine System

The endocrine system coordinates a wide array of body functions mainly through secretion of hormones and their actions on target tissues. Over the last decades, a collective effort between developmental biologists, geneticists, and stem cell biologists has generated a wealth of knowledge related to the contribution of stem/progenitor cells to both organogenesis and self-renewal of endocrine organs. This review provides an up-to-date and comprehensive overview of the role of tissue stem cells in the development and self-renewal of endocrine organs. Pathways governing crucial steps in both development and stemness maintenance, and that are known to be frequently altered in a wide array of endocrine disorders, including cancer, are also described. Crucially, this plethora of information is being channeled into the development of potential new cell-based treatment modalities for endocrine-related illnesses, some of which have made it through clinical trials

Global, regional, and national mortality among young people aged 10–24 years, 1950–2019: a systematic analysis for the Global Burden of Disease Study 2019

Summary: Background Documentation of patterns and long-term trends in mortality in young people, which reflect huge changes in demographic and social determinants of adolescent health, enables identification of global investment priorities for this age group. We aimed to analyse data on the number of deaths, years of life lost, and mortality rates by sex and age group in people aged 10–24 years in 204 countries and territories from 1950 to 2019 by use of estimates from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Methods We report trends in estimated total numbers of deaths and mortality rate per 100 000 population in young people aged 10–24 years by age group (10–14 years, 15–19 years, and 20–24 years) and sex in 204 countries and territories between 1950 and 2019 for all causes, and between 1980 and 2019 by cause of death. We analyse variation in outcomes by region, age group, and sex, and compare annual rate of change in mortality in young people aged 10–24 years with that in children aged 0–9 years from 1990 to 2019. We then analyse the association between mortality in people aged 10–24 years and socioeconomic development using the GBD Socio-demographic Index (SDI), a composite measure based on average national educational attainment in people older than 15 years, total fertility rate in people younger than 25 years, and income per capita. We assess the association between SDI and all-cause mortality in 2019, and analyse the ratio of observed to expected mortality by SDI using the most recent available data release (2017). Findings In 2019 there were 1·49 million deaths (95% uncertainty interval 1·39–1·59) worldwide in people aged 10–24 years, of which 61% occurred in males. 32·7% of all adolescent deaths were due to transport injuries, unintentional injuries, or interpersonal violence and conflict; 32·1% were due to communicable, nutritional, or maternal causes; 27·0% were due to non-communicable diseases; and 8·2% were due to self-harm. Since 1950, deaths in this age group decreased by 30·0% in females and 15·3% in males, and sex-based differences in mortality rate have widened in most regions of the world. Geographical variation has also increased, particularly in people aged 10–14 years. Since 1980, communicable and maternal causes of death have decreased sharply as a proportion of total deaths in most GBD super-regions, but remain some of the most common causes in sub-Saharan Africa and south Asia, where more than half of all adolescent deaths occur. Annual percentage decrease in all-cause mortality rate since 1990 in adolescents aged 15–19 years was 1·3% in males and 1·6% in females, almost half that of males aged 1–4 years (2·4%), and around a third less than in females aged 1–4 years (2·5%). The proportion of global deaths in people aged 0–24 years that occurred in people aged 10–24 years more than doubled between 1950 and 2019, from 9·5% to 21·6%. Interpretation Variation in adolescent mortality between countries and by sex is widening, driven by poor progress in reducing deaths in males and older adolescents. Improving global adolescent mortality will require action to address the specific vulnerabilities of this age group, which are being overlooked. Furthermore, indirect effects of the COVID-19 pandemic are likely to jeopardise efforts to improve health outcomes including mortality in young people aged 10–24 years. There is an urgent need to respond to the changing global burden of adolescent mortality, address inequities where they occur, and improve the availability and quality of primary mortality data in this age group